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imipenem brand name

[5][6], Patients who are allergic to penicillin, cephalosporins, and related drugs may react to imipenem. 750mg imipenem and 750mg cilastatin power mixture for intramuscular injection. More serious hepatic injury from imipenem/cilastatin is rare, but jaundice and liver test abnormalities have been reported in 0.1% of patients in prospective trials of the agent. Imipenem And Cilastatin (Intravenous Route, Intramuscular Route) Description and Brand Names - Mayo Clinic. The company that markets these medicines is Merck, Sharp & Dohme. Bacterial Infection. H2O that is derived from a bacterium (Streptomyces cattleya) and is effective against gram-negative and gram-positive bacteria. A recently published phase III study, The RESTORE IMI-1 demonstrated safety and tolerability in patients infected with carbapenem non-susceptible bacterial pathogens [ 3 ]. Buy Imipenem Online. In 2019, it was approved for use in the United States for the treatment of complicated urinary tract and complicated intra-abdominal infections. The medicine is available in all EU Member States under the trade name Tienam, as well under other trade names: Conet, Imipem, Primaxin, Tenacid and Zienam. For intravenous injection (administration). [5][6], It is a broad-spectrum beta-lactam containing equal quantities of imipenem and cilastatin. Imipenem-Cilastatin SODIUM Vial Side Effects by Likelihood and Severity COMMON side effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Imipenem/cilastatin/relebactam, sold under the brand name Recarbrio, is a fixed-dose combination medication used as an antibiotic. [7] It is made from a combination of imipenem and cilastatin. Cilastatin/imipenem systemic is used in the treatment of: Aspiration Pneumonia. It works by killing bacteria. [5] Find imipenem at best price offered by imipenem manufacturers, imipenem suppliers, dealers, traders and exporters. History of severe hypersensitivity to imipenem, cilastatin, or relebactam, or any other component. 500mg imipenem, 500mg cilastatin, and 20mg sodium bicarbonate power mixture for … The cause of the mild, transient serum enzyme elevations during imipenem-cilastatin therapy is not known. [6], World Health Organization's List of Essential Medicines, "Cilastatin / imipenem Use During Pregnancy | Drugs.com", "Imipenem and Cilastatin Sodium Injection", https://en.wikipedia.org/w/index.php?title=Imipenem/cilastatin&oldid=983527147, World Health Organization essential medicines, Chemical pages without DrugBank identifier, Multiple chemicals in an infobox that need indexing, Drugs that are a combination of chemicals, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 14 October 2020, at 19:00. Its use is generally restricted to severe infections largely in hospitalized patients. Several instances of cholestatic jaundice arising during or shortly after therapy have been reported with imipenem-cilastatin and other carbapenems. Get information of companies selling wide range of imipenem along with latest price, moq & product details. Contraindications. Imipenem-Cilastatin Suspension For Reconstitution. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. It works by stopping the growth of bacteria. OTHER NAME(S): Imipenem-Cilastatin Suspension For Reconstitution Imipenem/cilastatin is indicated for the treatment of severe or complicated skin, tissue, joint, respiratory tract, intra-abdominal, urinary tract and urogenital infections, but not meningitis (as it does not pass through the blood brain barrier), endocarditis, and sepsis due to susceptible organisms. [1] It is unclear if use during pregnancy is safe for the baby. Bronchitis. … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. - 500 INJECTION. Powder for solution for infusion 1 × 20ml Vial per pack. This antibiotic is used to treat serious infections that are mild to moderate in severity, such as lower respiratory infection, heart valve infection, infection caused by a burst appendix, and some abscesses. [6] Primaxin is cleared from the body by the kidneys, so it is important to tell one's doctor about any other drugs being taken that are also cleared through the kidneys (such as other antibiotics), especially for older patients, as kidney function declines with age. Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Imipenem inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins; cilastatin prevents renal metabolism of imipenem. For reasons that will be discussed, meropenem is not hydrolyzed by renal brush border dehydropeptidase. [1] It is given by injection into a vein or muscle. Chemical formula: C12H17N3O4SDrugbank ID: DB01598ATC code(s): J01DH51. [1] It is made from a combination of imipenem and cilastatin. * Tienam I.V. Overview. The brand name of the imipenem-cilastatin combination is Primaxin, and the prescribed dose of Primaxin is understood to refer to the amount of the imipenem component being administered. Recently, it was FDA approved for complicated intra-abdominal (cIA)and urinary tract infections (cUTI) under the brand name Recarbrio ®. Bacteremia. [1] Other side effects may include Clostridium difficile diarrhea and allergic reactions including anaphylaxis. Cautions. This medicine is also used to treat hospital-acquired and ventilator-associated bacterial pneumonia. Imipenem is a broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem and other carbapenems have not been linked to cases of acute liver failure. Imipenem. [2] Imipenem is in the carbapenem family of medications and works by interfering with the bacteria's cell wall. Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Excretion (both drugs): Urine (~70% as unchanged drug), Primaxin IV is a combination of imipenem, cilastatin sodium, and sodium bicarbonate which is added as a buffer. How to use imipenem in a sentence. 1907/2006 as amended by (EC) No. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. viridans- group streptococci, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species. Imipenem is a beta-lactam antibiotic that is used in combination with cilastatin to treat infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc. 1 vial EV 500 mg + 500 mg. Approval Date. BRAND NAME(S): Primaxin. Imipenem and Cilastatin Sodium. Side Effects. *Please select more than one item to compare Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage. Drug Name : Imipenem and Cilastatin Imipenem and Cilastatin (Primaxin) generic is a … Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for imipenem. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Professional. Developmental toxicity studies with imipenem and cilastatin sodium (alone or in combination) administered to mice, rats, rabbits, and monkeys at doses 0.4 to 2.9 times the recommended human dose (RHD), (based on body surface area), showed no drug-induced fetal malformations Imecitin. The .gov means it’s official. [1] Cilastatin blocks the activity of dehydropeptidase I which prevents the breakdown of imipenem. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. USES: This medication is used to treat a wide variety of bacterial infections.This medication is known as a carbapenem-type antibiotic. The recommended dosage is 250 mg to 1 gram given intravenously every 6 to 8 hours or in intramuscular doses of no more than 1.5 gm daily, usually for five to 14 days. Structure, Function, and Resistance Important: The information below refers to products available in the United States that contain imipenem. Last updated on Oct 16, 2020. Imipenem and Cilastatin. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics. It is important tell one's doctor or pharmacist one's medical history, especially of brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, and stomach/intestinal diseases (e.g., colitis).[5]. Some patients may benefit from symptomatic therapy of the pruritus associated with cholestasis using antihistamines, ursodiol, or cholestyramine. cilastatin/imipenem systemic. It is given by injection into a vein or muscle. [5], Common side effects for both forms are:[7], Major side effects requiring medical attention:[7], This medicine is passed through breast milk, so its use during pregnancy or breastfeeding should only be done when clearly needed. Little information is available on possible cross-sensitivity to liver injury among the different betalactam antibiotics, but patients with clinically apparent liver injury due to imipenem should probably avoid the other carbapenems. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Imipenem (hydrate) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. The drug is distributed rapidly and widely to most tissues and fluids, including sputum, pleural fluid, peritoneal fluid, interstitial fluid, bile, aqueous humor, reproductive organs, and bone; highest concentrations occur in pleural fluid, interstitial fluid, peritoneal fluid, and reproductive organs; low concentrations occur in CSF; it crosses the placenta, and enters breast milk. Primaxin IM lacks the sodium bicarbonate buffer. Imipenem/cilastatin has the ability to kill a wide variety of bacteria. Federal government websites often end in .gov or .mil. Cilastatin is in a class of medications called dehydropeptidase inhibitors. Immunoallergic features can occur, but autoantibodies are rare. Dosage. Intravenous: 250mg imipenem, 250mg cilastatin, and 10mg sodium bicarbonate power mixture for intravenous injection. [9] Imipenem is metabolized in the kidney by dehydropeptidase 1; activity is blocked by cilastatin. The course is usually self-limiting, but at least one case of vanishing bile duct syndrome related to the carbapenems has been reported. Search results for imipenem at Sigma-Aldrich. Drug class (es): carbapenems. Tore Midtvedt, in Side Effects of Drugs Annual, 2011. *Please select more than one item to compare The most common side effects of imipenem are diarrhea, nausea, vomiting, skin rash, pruritus, and injection-site reactions. Dosage Strength. Continue Learning about Antibiotic 6 Ailments That Call for an Antibiotic Compare Products: Select up to 4 products. In large clinical trials, imipenem was associated with transient and asymptomatic elevations in serum aminotransferase levels in about 6% of patients given the drug for five to 14 days. 1 × 20ml Vial. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Brand Name. The latency to onset has been within one to three weeks, and the pattern of enzyme elevations is usually cholestatic. What is imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)? Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Descriptions Imipenem, cilastatin, and relebactam combination injection is used to treat complicated bacterial infections in many different parts of the body (eg, kidneys, stomach). Primaxin is an antibiotic useful for the treatment of a number of bacterial infections. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [1], Imipenem/cilastatin was first sold in 1987. “Primaxin” the brand of Originator Merck & Co. contains Imipenem & Cilastatin, a new beta-lactam agent of the carbapenem class (1-Beta-methyl carbapenem). Half-life (both drugs): 60 min; prolonged with renal impairment. Imipenem-cilastatin-relebactam Injection FDA Identified Breakpoints. Medically reviewed by Drugs.com. Imipenem (hydrate) SAFETY DATA SHEET Supersedes Revision: 10/28/2014 according to Regulation (EC) No. Imipenem+Cilastatin+500500 Mg 1 Unit Parenteral Use. Imipenem/Cilastatin is a topic covered in the Johns Hopkins ABX Guide.. To view the entire topic, please sign in or purchase a subscription.. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. It is commercially available as Primaxin as 250-mg or 500-mg infusion bottles for IV use or 500-mg or 750-mg vials of lyophilized powder for IM injection. The liver injury due to the carbapenems is usually mild and self-limited. The cholestatic hepatitis attributed to imipenem-cilastatin and the carbapenems is probably immunoallergic and resembles the rare, clinically apparent liver injury that has been linked to penicillins and cephalosporins. If experienced, these tend to have a Severe expression. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. COMMON BRAND(S): Primaxin. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections. Bone infection. As a result, the antibiotic stays in the body and can work for longer. It … Rarely, the carbapenems can cause a clinically apparent acute cholestatic hepatitis that is usually self-limiting and not requiring therapy or intervention. Generic Name: Imipenem and Cilastatin (i mi PEN em & sye la STAT in) Brand Name: Primaxin I.V. Brand names: Primaxin IV, Primaxin IMDrug class(es): carbapenemsCilastatin/imipenem systemic is used in the treatment of: Brand names: RecarbrioDrug class(es): carbapenems/beta-lactamase inhibitorsCilastatin/imipenem/relebactam systemic is used in the treatment of: → Search the entire Drugs.com site for imipenem. Imipenem/cilastatin was approved for use in the United States in 1985. Brand names: Primaxin IV, Primaxin IM. Search results for Imipenem at Sigma-Aldrich. * Each vial contains: Imipenem monohydrate equivalent to 500 mg imipenem anhydrous, and Cilastatin sodium equivalent to 500 mg Cilastatin acid, with 21 mg Sodium Bicarbonate. [3] It is on the World Health Organization's List of Essential Medicines. [4], Imipenem/cilastatin is used for lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecologic infections, bacterial sepsis, bone and joint infections, skin and skin structure infections, endocarditis and polymicrobic infections. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Its chemical name is [5 R - [5α, 6α (R *)]]-6- (1-hydroxyethyl) -3- [ [2- [ (iminomethyl) amino] ethyl]thio]-7-oxo-1-azabicyclo [3.2.0] hept … 1.1 Related SourceWatch articles; 1.2 References; 1.3 External resources; 1.4 External articles; Articles and resources In patients with vanishing bile duct syndrome, corticosteroids are often used but have not been shown to be beneficial and are best avoided. Imipenem (trade name Primaxin among others) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Application Number. 1272/2008 1.1 Product Code: 16039 Section 1. Compare Products: Select up to 4 products. It works by helping i… GENERIC NAME(S): Imipenem-Cilastatin. View all Brand Names Innovator's Monograph Indications The activity of Cilastatin & Imipenem against an unusually broad spectrum of pathogens makes it particularly useful in the treatment of polymicrobic mixed aerobic/anaerobic infections as well as initial therapy prior to … [1] Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. 1 Articles and resources. [1], Common side effects include nausea, diarrhea, and pain at the site of injection. The brand name for imipenem and cilastatin is Primaxin. caused by various types of bacteria. Available for Android and iOS devices. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem; Imipenem/cilastatin (Brand name: Primaxin) Doripenem (Brand name: Doribax) Meropenem (Brand name: Merrem) Ertapenem (Brand name: Invanz) Contents. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. Imipenem is in a class of medications called carbapenem antibiotics.

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