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iranian journal of basic medical sciences

P63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers, Association of ADAM33 gene polymorphisms with allergic asthma, Seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A antibodies among healthy individuals in center of Iran, Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats, The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family, Effect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats, Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats, Effect of leptin receptor Q223R polymorphism on breast cancer risk, Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy, Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum, Cloning and expression of the enzymatic region of Streptococcal hyaluronidase, Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method, Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle, Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice, Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion, The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus, The Effect of Chronic Administration of Aegle Marmelos Seed Extract on Learning and Memory in Diabetic Rats, Role of NADPH Oxidase in the Endothelial Dysfunction and Oxidative Stress in Aorta of Aged Spontaneous Hypertensive Rats, Design of Agglomerated Crystals of Ibuprofen During Crystallization: Influence of Surfactant, Effect of temperature on wet agglomeration of crystals, Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats, Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats, Immunohistological and electrophysiological characterization of Globose basal stem cells, Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes, Bioscreening of Oxypeucedanin, a Known Furanocoumarin, Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus, Preparation and Evaluation of Poly (-caprolactone) Nanoparticles-in-Microparticles by W/O/W Emulsion Method, Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats, Comparison of the genetic convergence between mycobacterium strains by three RFLP-based methods in central province of Iran, The Differences in the Relaxant Effects of Different Fractions of Rosa damascena on Guinea Pig Tracheal Smooth Muscle, Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats, Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma, MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF), MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation, Restoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: Implications and applications in functional assay development, Quercetin protects PC-12 cells against hypoxia injury by downregulation of miR-122, Downregulation of microRNA-125a is involved in intervertebral disc degeneration by targeting pro-apoptotic Bcl-2 antagonist killer 1, First report of OXA-143-lactamase producing Acinetobacter baumannii in Qom, Iran, instructions how to enable JavaScript in your web browser. After peer-review by expert national and international reviewers, 15 % of submitted papers were accepted for publication. Additionally, BAK1 is the target gene of miRNA-125a. The use of antisense oligonucleotides (AOs) to restore normal splicing by blocking the recognition of aberrant splice sites by the spliceosome represents an innovative means of potentially controlling certain inherited disorders affected by aberrant splicing. RORC and FOXP3 were up-regulated in relapsing and remitting phases of MS, respectively. A recombinant plasmid (pEGFP/I-110) carrying the EGFP gene interrupted by a mutated human β-globin intron 1 (IVSI-110) was developed and transfected into K562 cells. Materials and Methods: Results: We studied 98 prostate biopsy blocks (40 adenocarcinoma and 58 benign lesions) for basal cell marker expression. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Haemodynamic measurements included pulmonary artery pressure and right ventricular hypertrophy. It has been notified that ion channels' activities in cardiomyocytes are sensitive to the ATP level. The study searched about 40% of the entire mitochondrial genome in the family. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, … The agglomeration of crystals was carried out at various temperatures and the agglomerates were characterized in terms of size, morphology, density and mechanical strength. Experimental rats were fed with high fructose diet for 6 weeks and then were treated with Z. multiflora extract or a pioglitazone solution for 2 weeks. This cellular splicing assay provides a novel functional assay system in assessing the cellular delivery efficiency of AOs and therapeutic effect of AOs in restoration of aberrant splicing. A Statistically significant correlation (r = 0.737) between QTc (ms) and the age of LQTS patients has been reported. Objective(s)As an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. Materials and Methods Crystallization of ibuprofen was carried out using the quasi emulsion solvent diffusion method in presence of surfactant (sodium lauryl sulfate (SLS), Tween 80). For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. Objective(s): Finally, the 1:1 mixture of naproxen and each excipient was tabletted, and hardness and friability of different tablets were evaluated. Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. The Journal welcomes original clinical articles as well as basic science research experiences mainly on prevalent diseases in the region and the analysis of various regional problems. Results: The number of pyramidal neurons in CA1, CA2 and CA3 in treated groups was significantly reduced in postnatal day 18 and 32 (P18, P32) compared to control groups (P<0.05). This study demonstrates the beneficial effects of Zataria multiflora extract on insulin resistance in rats fed with a high-fructose diet through at least three mechanisms including direct insulin like effect, increasing in adiponectin and of PPARγ protein expression. Iranian Journal of Basic Medical Sciences (Print) Document Type: Journal / Magazine / Newspaper: ISSN: 2008-3874: OCLC Number: 1076664907: Other Titles: Iranian Journal of Basic Medical Sciences: Reviews. Results: The Journal Impact 2019-2020 of Iranian Journal of Basic Medical Sciences is 1.960, which is just updated in 2020. In the present work, we focused on some bioactive aspects of it.Materials and MethodsIn the present work, the compound was purified from Prangos uloptera using TLC and its phytotoxic, antibacterial, antifungal, antioxidant and cytotoxic effects were evaluated by Lettuce assay, disc diffusion method, mycelia radial growth, DPPH and MTT assays, respectively.Results Our results revealed that oxypeucedanin exhibit considerable phytotoxic activity and might play an allelopathic role for plants. Edited by: Muzafer Mujic, MD, PhD and Semir Vranic, MD, PhD. Degree of pulmonary vascular remodeling was determined by Hematoxylin and Eosin (HE) staining. Conclusion: All 5 groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 50; 100; and 200 mg/KgBW. Objective(s)Ibuprofen is a problematic drug in tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surface. The drug release was found to be diffusion and erosion controlled.Conclusion Objectives: Voltage gated Na+ channels were completely absent, which proves the unexcitable nature of GBCs. The antigenic property of the produced protein is well retained. Objective(s): Medicinal uses The local inhabitants of rural areas are aware of inherent properties of various plants. Materials and methods: Using reference management software Typically you don't format your citations and bibliography by hand. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. In nanoparticles, F4 formulation (0.4:1 drug/polymer ratio) showed high production yield (40.8%), loading efficiency (99.05%), low particle size (756 nm) and minimum burst effect compared with other nanoparticle formulations. Relative miR-122 expression in Quer-treated cells or transfection efficacy of miR-122 was analyzed by qRT-PCR. In each group of animals, spatial learning and memory parameters were analyzed. 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. This work also throws some light on ionic channels present on these stem cells which are responsible for their neuron induction potential. Objective(s): Results: Basic and Clinical Neuroscience (BCN) is an open-access journal, which is the official publication of Iran University of Medical Sciences and the Iranian Neuroscience Society. All the interventions were done during pregnancy (21 days). The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release.Materials and Methods The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. Conclusion: Morphine administration before and during pregnancy and during lactation period causes pyramidal neurons loss in 18 and 32 days old infant mice. The increase in the protein expressions of CD11a, CD11b, and CD11c integrins may have an important role in the occurrence and development of myocardial hypertrophy. Our results showed that co-administration of nano-silver and garlic during pregnancy may lead to reduce nano-silver induced apoptotic cells in their offspring hippocampus. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the thoracic level. The risk factors of clustering among tuberculosis patients were age < 45 years, new cases, degree of sputum smear ≥ 2+, and close contact. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. We also found that AMPK and Wnt/β-catenin signaling pathways were activated by Quer in hypoxia-induced injury, but were inactivated in hypoxia-induced cells by overexpression of miR-122. The journal publishes basic and translational/clinical research submissions in all biomedical specialties, including Genetics and Molecular biology, Immunology, Microbiology, Pathology, Biochemistry, Pharmacology, Anatomy, Biomaterials, new and emerging research and diagnostic methods, new and emerging medical entities, and others. Leaky K+ channels were found to be present on the GBC which was of no significance. The Journal of "IJBMS” is a modern forum for scientific communication. The aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. The antimicrobial susceptibility of isolates was tested by standard disk diffusion and prevalence of bla OXA genes was investigated by PCR method. The aim of this study was to determine the seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A (CagA) antibodies in asymptomatic healthy population in the center of Iran and to investigate the relation with different parameters. Results: Iranian Journal of Basic Medical Sciences . Asthma results from the interaction between genetic and environmental factors. The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . Myocardial tissues were obtained, embedded in conventional paraffin, sectioned, and stained with hematoxylin. Because of the bad compaction behavior ibuprofen has to be granulated usually before tableting. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Materials and Methods: Thirty female mice were randomly allocated into cases and controls. 22, No. ijbms.mums.ac.ir Iranian Journal of Basic Medical Sciences In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme Azizeh Asadzadeh 1, Hajar Sirous 2, Morteza Pourfarzam 2, Parichehreh Yaghmaei 1, Afshin Fassihi 3* 1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran The Iranian Journal of Medical Sciences (IJMS) is an international peer-reviewed bimonthly biomedical publication, the aim of which is to provide a scientific medium of communication for researchers throughout the globe. Materials and Methods However, it would be more satisfactory to obtain directly during the crystallization step crystalline particles that can be directly compressed and quickly dissolved. The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. Expression pattern of miR-9-5p and miR-106a-5p and their targets suggest a possible inducing role of miR-9-5p and suppressing role of miR-106a-5p in differentiation pathway of Th17 cells during MS pathogenesis. In the current study formulations were characterized by loading efficiency, yield, particle size, zeta potential, X-ray diffraction (XRD) and differential scanning calorimetry (DSC).ResultsIn microparticles, the best drug to polymer ratio was 0.8:1 (F3). We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Quer could repress hypoxia-induced injury in PC-12 cells by activating AMPK and Wnt/β-catenin signaling pathways via down-regulation of miR-122. Materials and Methods Iranian journal of basic medical sciences 16 (10), 1031, 2013. Iranian Journal of Basic Medical Sciences Journal Profile. Results All patients were graded according to the Pfirrmann criteria. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agglomerates. Totally, 525 individuals aged 17-60 years were enrolled in study. When categorizing the asthmatic patients in severe, moderate and mild groups, associations in the subcategories of asthmatic patients were found. Materials and Methods: Inhibition of miR-103 could promote ischemic stroke angiogenesis and reduce infarction volume via enhancing VEGF, which provides a new target for the clinical treatment of ischemic stroke. Results D. aucheri could be useful in treatment of diabetes. injection of streptozotocin (45 mg/kg). Animals were treated for 4 weeks by A. marmelos or normal saline. 【Iranian Journal of Basic Medical Sciences】CiteScore Trend: Comments from Authors * All review process metrics, such as acceptance rate and review speed, are limited to our user-submitted manuscripts. Moreover, we examined the effect of in vitro inhibition of NADPH oxidase by apocynin or the novel NADPH oxidase inhibitor, VAS2870 on the vascular reactivity and ROS production.ResultsOur results showed that ROS formation was largely increased in aorta of SHR as measured by dihydroethidine (DHE) fluorescence and inhibited by apocynin or VAS2870. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. QRT-PCR was used to detect the expression of miR-125a and BAK1, and apoptosis of NP tissues detected by TUNEL staining. The XRPD and DSC results showed that during the agglomeration process, ibuprofen did not undergo any polymorphic changes.Conclusion The study highlights the influence of surfactants on crystallization process leading to modified performance. Changes in the mRNA expressions of CD11a, CD11b, and CD11c in the myocardial tissues of rats were detected by RT-PCR. ISO 4 (Information and documentation – Rules for the abbreviation of title words and titles of publications) is an international standard, defining a uniform system for the abbreviation of serial publication titles. Moderate dose of D. aucheri (200 mg/kg) was more effective than the others. This editorial deals with the state of the Iranian Journal of Basic Medical Sciences (IJBMS) in 2013. MESA100 and MESA200 also elevated the EPCs number compared with hypertensive group. The seroprevalence of anti-CagA IgG was in males 48.6% and in females 31.6%. … Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract.Conclusion Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. Rats were injected with saline or ropivacaine. Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. This effect could be attributed to hypoglycemic, hypolipidemic and antioxidant activity of A. marmelos. Iran J Basic Med Sci, Vol. ResultsIbuprofen particles obtained in the presence of surfactants consisted of numerous plate- shaped crystals which had agglomerated together as near spherical shape. Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. Quasi-emulsion solvent diffusion was used as a crystal modification method. Aegle marmelos Corr. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Results: This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Iranian Journal of Basic Medical Sciences (IJBMS) as one of the foremost regional publications in its field has contributed significantly to this national effort. Conclusion: Comparison between patients and healthy subjects regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes in patients with PCAG (P=0.03). These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen. The tail flick latency was dose dependently enhanced by the extract but this was significantly (P< 0.05) lower than that produced by morphine (10 mg/kg). 167: The administration of MESA100 and MESA200 elevated the total plasma nitrate/nitrite levels but cannot reach the level in control group. miR-122 overexpression decreased cell viability and migration, and increased cell apoptosis in hypoxia- treated PC-12 cells, but miR-122 silencing led to the opposite results. Plasma free fatty acids profile was studied by gas chromatography. Data also indicated that enzymatic region of hyaluronidase protein from Streptococcus pyogenes was recognized in all 5 patient's sera. Moreover, hypoxia increased expression of CREB at mRNA and protein levels which could be suppressed by thoracic epidural blockade. Thus, FOXP3 and RAR-related orphan receptor γt (RORγt) was assessed in CD4⁺T-cells by flow cytometry. Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with primary open angle glaucoma (PCAG), and 59 with primary closed angle glaucoma (POAG)) compared to 100 healthy subjects. When transfection of miR-125a mimics in vitro, the apoptosis of NPCs were inhibited, with the down-regulation of BAK1, Caspase-3, and Bax, and the upregulation of Bcl-2. Iranian Journal of Basic Medical Sciences comes of age on the 20 th anniversary of publication Iran J Basic Med Sci . ResultsIn group 1, all concentrations of theophylline, ethyl acetate fraction and two final concentrations of n-butanol fraction showed significant relaxant effects in comparison with saline (p< 0.05 to P< 0.001). There was a significant association between sensitivity to mite and polymorphism of C allele of T1 SNP (P=0.02). The dissolution tests showed that the agglomerates obtained in presence of SLS exhibited enhanced dissolution rate while the agglomerates made in the presence of Tween 80 had no significant impact on dissolution rate of ibuprofen in comparison to untreated sample. Besides, in OGD human umbilical vein endothelial cells (HUVECs), inhibition of miR-103 could promote the increase of tube length and the migration of cells. Cerebrum of six offsprings in each group was removed and stained with cresyl violet and a monoclonal antibody NeuN for immunohistochemical detection of surviving pyramidal neurons. Selection of the appropriate target site is essential in the success of an AO therapy. The control animals received an equivalent volume of normal saline. Solvent systems consist of ethyl acetate and dichloromethane for microspheres and nanospheres, respectively. These results showed that H. pylori infection was common in the asymptomatic individuals. Among carbapenem resistant isolates, 100% carried blaOXA-51-like, 82.47% carried blaOXA-23-like, 55.67% carried blaOXA-58-like, 22.68% carried blaOXA-40-like and 14.43% had blaOXA-143-like resistance genes. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression of miRNAs and mRNAs, in 40 RR-MS patients and 11 healthy individuals. Objective(s)Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. In general, it is possible to produce the enzymatic regions of the Streptococcus pyogenes hyaluronidase in E. coli. Objective(s)Increased reactive oxygen species (ROS) production is implicated in the pathogenesis of arterial hypertension and the development of endothelial dysfunction. Among 97 carbapenem non-susceptible isolates of A. baumannii, 90.72% (88 isolates) isolates showed extensive drug resistance to multiple antibiotics. The Journal of "IJBMS” is a modern forum for scientific communication. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. Journal Abbreviation: IRAN J BASIC MED SCI Objective(s): NADPH oxidase type enzyme family has been suggested to form ROS and to interfere with endothelium-dependent relaxation. User-contributed reviews Tags. The results revealed a significant increase of hippocampus nano-silver level in N.S and N.S+G groups comparing to N group (P<0.05) and a significant decrease in nano-silver level in N.S+G group comparing to N.S group (P<0.01). Conclusion: Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. Investigation of interaction of adenine nucleotide transposes (ANT) and cyclophilin-D with porin by Western blotting showed no proteins co-purified with porin from injured tissues.Conclusion The present study implies that there may not be interaction between porin, and ANT or cyclophilin-D, and if there is any, it is not maintained during the purification procedure.

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