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iranian journal of basic medical sciences

The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Significantly more FN, Smad3 and IGFBPrP1 were expressed in treatment groups than those in normal group. There were significant correlations between the relaxant effects and concentrations for theophylline and all fractions (except aqueous fractions in group 1) in both groups. All patients were graded according to the Pfirrmann criteria. Conclusion: The enzymatic region of hyaluronidase gene was detected by bioinformatics method. A number of AOs with a 2'-O-methyl oligoribonucleotide (2'-O-Me) backbone system were systematically tested in this cellular splicing assay. nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D. aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for 4 weeks. Degree of pulmonary vascular remodeling was determined by Hematoxylin and Eosin (HE) staining. Materials and methods: Thiamine pyrophosphate prevents infertility through an as yet unknown mechanism. The administration of MESA100 and MESA200 elevated the total plasma nitrate/nitrite levels but cannot reach the level in control group. The objective of the present study was to clone and express the nucleotide sequence of the enzyme which is involved in hyaluronidase enzymatic activity. Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract.Conclusion Meanwhile, si-VEGF could reverse the effect of miR-103 inhibitor on angiogenesis in rats subjected to MCAO. F3 formulation had minimum burst effect (37.81%), high loading efficiency (95.88%). Carbamazepine was used as a model drug and water/ethanol and isopropyl acetate were used as crystallization system and binder liquid, respectively. In this study, in search for a splice model system to facilitate the evaluation of AOs to redirect defective splicing of IVSI-110 β-globin intron, an EGFP-based IVSI-110 specific cellular reporter assay system has been developed and a number of AOs were tested in this cellular splicing assay. Hypoxia-induced increase in levels of serum cGMP and TNF-α was reversed by thoracic epidural blockade. The XRD and DSC showed stable character of theophylline in the drug loaded microspheres. The mutation in the intron causes aberrant splicing of EGFP pre-mRNA, preventing translation of EGFP; however, treatment of the cells with specific concentration of a sequence specific 2'-O-Me AO targeted to the aberrant splice site induced correct splicing and resulted in restoring of EGFP activity. In addition, the effect of ethyl acetate fraction in group 1 was significantly higher than those of theophylline (p< 0.05 to p< 0.001). Conclusion: The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique. The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agglomerates. Mild hypothermia decreases infarct volume after cerebral ischemia-reperfusion, reduces Fas and MMP-3 expression, but increases FasL in cerebral ischemia-reperfusion rats. 【Iranian Journal of Basic Medical Sciences】CiteScore Trend: Comments from Authors * All review process metrics, such as acceptance rate and review speed, are limited to our user-submitted manuscripts. Objective(s)Ibuprofen is a problematic drug in tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surface. We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method to investigate the association of LEPR Q223R polymorphism with breast cancer risk in a case control study consisting of 100 breast cancer cases and 100 controls without breast cancer. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the thoracic level. Iranian Journal of Basic Medical Sciences Inactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes G Karimi, M Vahabzadeh, P Lari, M Rashedinia, M Moshiri. However, the specific isoform of NADPH oxidases that may predominantly contribute to these events remains to be clarified. Conclusion: Blood glucose, serum level of triglyceride and cholesterol were measured by auto analyzer. Extraction of DNA from Mycobacterium strains and DNA fingerprinting with IS-6110, PGRS and DR probe were performed by standard protocols. Objective(s)Increased reactive oxygen species (ROS) production is implicated in the pathogenesis of arterial hypertension and the development of endothelial dysfunction. Results: The number of pyramidal neurons in CA1, CA2 and CA3 in treated groups was significantly reduced in postnatal day 18 and 32 (P18, P32) compared to control groups (P<0.05). Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. Haemodynamic measurements included pulmonary artery pressure and right ventricular hypertrophy. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. ISO 4 (Information and documentation – Rules for the abbreviation of title words and titles of publications) is an international standard, defining a uniform system for the abbreviation of serial publication titles. QRT-PCR was used to detect the expression of miR-125a and BAK1, and apoptosis of NP tissues detected by TUNEL staining. Results: Iranian journal of basic medical sciences 16 (10), 1031, 2013. The risk factors of clustering among tuberculosis patients were age < 45 years, new cases, degree of sputum smear ≥ 2+, and close contact. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. Quantitative computer-assisted morphometric study was done on hippocampus. The study searched about 40% of the entire mitochondrial genome in the family. Expressions of FN, Smad3, IGFBPrP1 and TGF-β1 genes were detected by Western Blot and immunohistochemical assays. 4- Garlic group (G); garlic juice (1 ml/100 g) administrated via gavage, 5- normal (N) without any intervention. Almost half of the infected individuals acquire CagA-positive strains of H. pylori. There was statistically inverse association between H. pylori infection and education level (P=0.04) and marital status (P=0.000). Larger and well shaped agglomerates were formed which showed different thermal behavior. Apoptotic index of model group was significantly higher than that of normal group, but indices of CG-V and CG-VII groups were significantly lower than that of model group. This is a short guide how to format citations and the bibliography in a manuscript for Iranian Journal of Basic Medical Sciences (IJBMS). Iranian Journal of Basic Medical Sciences Journal Profile. Hepatic fibrosis of treatment groups was evidently mitigated. This cellular splicing assay provides a novel functional assay system in assessing the cellular delivery efficiency of AOs and therapeutic effect of AOs in restoration of aberrant splicing. The Journal is an editorially independent double-blinded peer reviewed online open access journal owned and published by Iran University of Medical Sciences and aims to be a publication of international repute for reporting current regional and international adventures in all aspects of the medicine. Data also indicated that enzymatic region of hyaluronidase protein from Streptococcus pyogenes was recognized in all 5 patient's sera. The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. Materials and methods: Results Quasi-emulsion solvent diffusion was used as a crystal modification method. 6, Jun 2013 773 symptoms such as parenthesis, ataxia, dementia, depression and psychosis (2). The Journal Impact Quartile of … GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. When categorizing the asthmatic patients in severe, moderate and mild groups, associations in the subcategories of asthmatic patients were found. For this purpose, we used in vivo 4-vessel occlusion model of rat brain and porin purification method by hydroxyapatite column. This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population. The Standard Abbreviation (ISO4) of Iranian Journal of Basic Medical Sciences is “Iran J Basic Med Sci”. This editorial deals with the state of the Iranian Journal of Basic Medical Sciences (IJBMS) in 2013. Conclusion: We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. The journal publishes basic and translational/clinical research submissions in all biomedical specialties, including Genetics and Molecular biology, Immunology, Microbiology, Pathology, Biochemistry, Pharmacology, Anatomy, Biomaterials, new and emerging research and diagnostic methods, new and emerging medical entities, and others. GSP have protective effects against hepatic tissue injury due to antioxidant properties. Bacopa monnieri (BM), a traditional ayurvedic medicine, is a well-known memory enhancer. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, … Conclusion: from Rutaceae family is widely used in Iranian folk medicine for the treatment of diabetes mellitus. The sample of the research was an Iranian family with LQTS for mutations by PCR-SSCP and DNA sequencing. Infarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P<0.05). Conclusion: Iranian Journal of Basic Medical Sciences (Print) Document Type: Journal / Magazine / Newspaper: ISSN: 2008-3874: OCLC Number: 1076664907: Other Titles: Iranian Journal of Basic Medical Sciences: Reviews. Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). We addressed the hypothesis that porin interacts with other mitochondrial proteins after ischemic injury.Materials and Methods Blood and tissue samples were collected for analysis at the end of two weeks. Besides, in OGD human umbilical vein endothelial cells (HUVECs), inhibition of miR-103 could promote the increase of tube length and the migration of cells. We found the reduced miR-103 in rats after MCAO. Circulating endothelial cells (CECs) and EPCs were assayed using flow cytometry. However, it would be more satisfactory to obtain directly during the crystallization step crystalline particles that can be directly compressed and quickly dissolved. In addition, siBAK1 can reverse the pro-apoptosis function of miR-125a inhibitors in NPCs. The study demonstrated that A. marmelos has significant protective affect against diabetes-induced spatial learning and memory deficits. Materials and Methods: Objectives: This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran. Quer alleviated hypoxia-induced injury in PC-12 cells by increasing viability, promoting cell proliferation, enhancing migration and repressing apoptosis. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Journal Abbreviation: IRAN J BASIC MED SCI The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, open access, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . The number of TUNEL positive cells in the CA1, CA3, and DG fields of rat offspring hippocampus increased in N.S and N.S+G groups comparing to other ones, and also reduced significantly in N.S+G group comparing to N.S group ((¥) P< 0.01). Higher temperature of the system during agglomeration process favors the formation of more regular agglomerates with mechanically stronger and denser structure; this can be explained by the promotion effect of temperature on the agglomeration process. FIFTY PREGNANT WISTAR RATS WERE RANDOMLY DIVIDED INTO FIVE GROUPS: 1- nano-silver (N.S) group; 30 mg/kg of N.S treated via gavage. P63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers, Association of ADAM33 gene polymorphisms with allergic asthma, Seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A antibodies among healthy individuals in center of Iran, Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats, The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family, Effect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats, Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats, Effect of leptin receptor Q223R polymorphism on breast cancer risk, Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy, Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum, Cloning and expression of the enzymatic region of Streptococcal hyaluronidase, Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method, Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle, Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice, Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion, The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus, The Effect of Chronic Administration of Aegle Marmelos Seed Extract on Learning and Memory in Diabetic Rats, Role of NADPH Oxidase in the Endothelial Dysfunction and Oxidative Stress in Aorta of Aged Spontaneous Hypertensive Rats, Design of Agglomerated Crystals of Ibuprofen During Crystallization: Influence of Surfactant, Effect of temperature on wet agglomeration of crystals, Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats, Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats, Immunohistological and electrophysiological characterization of Globose basal stem cells, Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes, Bioscreening of Oxypeucedanin, a Known Furanocoumarin, Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus, Preparation and Evaluation of Poly (-caprolactone) Nanoparticles-in-Microparticles by W/O/W Emulsion Method, Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats, Comparison of the genetic convergence between mycobacterium strains by three RFLP-based methods in central province of Iran, The Differences in the Relaxant Effects of Different Fractions of Rosa damascena on Guinea Pig Tracheal Smooth Muscle, Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats, Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma, MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF), MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation, Restoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: Implications and applications in functional assay development, Quercetin protects PC-12 cells against hypoxia injury by downregulation of miR-122, Downregulation of microRNA-125a is involved in intervertebral disc degeneration by targeting pro-apoptotic Bcl-2 antagonist killer 1, First report of OXA-143-lactamase producing Acinetobacter baumannii in Qom, Iran, instructions how to enable JavaScript in your web browser. The bacteria including pET32a-hylA (hylA is abbreviation of Streptococcus pyogenes hyaluronidase gene and hylA is abbreviation of Streptococcus pyogenes hyaluronidase protein) plasmids were induced by IPTG and analyzed by SDS-PAGE. To our knowledge, there are few reports on pharmacological and biological activities of this compound. Our results showed that the LEPR Q223R polymorphism is associated with increased breast cancer risk as well as tumor grade in a sample of Iranian subjects. Objective(s): Materials and Methods Materials and Methods Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. Results: The agglomerates size and size distribution was largely controlled by surfactant concentration, but there was no significant influence found on the tableting properties. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. on Leishmania major infection in BALB/c mice Linet T Laban 1, Christopher O Anjili 2, Joshua M Mutiso 1, Johnstone Ingonga , Samuel G Kiige 1, Mgala M Ngedzo , Michael M Gicheru 1* GSTM1 and GSTT1 null deletions genotypes were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy subjects. Dual-luciferase assay was used for analyzing the targeting relationship between miR-103 and VEGF. MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Besides, there was a significant association between sensitivity to weeds and genotype GG of V4 SNP (P=0.05). GBCs could be isolated in pure (99% purity) form and were found to be stained positive for all neural progenitor cell markers. Objective(s): Objective(s)Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Journal Abbreviation: IRAN J BASIC MED SCI. Objectives: Results: The control animals received an equivalent volume of normal saline. Iranian Journal of Basic Medical Sciences | Citations: 429 | Read 757 articles with impact on ResearchGate, the professional network for scientists. Helicobacter pylori infection occurs worldwide, but the prevalence of this infection varies greatly among different countries and population groups. Iranian Journal of Basic Medical Sciences. Conclusion miR-122 overexpression decreased cell viability and migration, and increased cell apoptosis in hypoxia- treated PC-12 cells, but miR-122 silencing led to the opposite results. To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. In a cross-sectional and prospective study, 95 strains of M. tuberculosis isolates were selected for DNA fingerprinting. The most prevalent blood group was type AB with positive Rh-phenotype (82.4%). Objective(s): Conclusion However, the effects of other fractions were significantly lower than theophylline in both groups (p< 0.01 to p< 0.001). We also characterized these cells immunohistologically using various pluripotent stem cell markers. Finally, the brains of rat offspring were removed to use for nano-silver level measurement and TUNEL staining. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Immunohistochemical results showed that the positive expressions of CD11a, CD11b, and CD11c integrins increased significantly in the experimental group compared with those in the control group. As such they may not reflect the journals' exact competitiveness or speed. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression of miRNAs and mRNAs, in 40 RR-MS patients and 11 healthy individuals. GSTM1and GSTT1 polymorphisms were determined by multiplex polymerase chain reaction. Enzymes digestion analysis, sequencing results showed that the target gene (1296 base pair) was inserted correctly into the recombinant vector. Additionally, BAK1 is the target gene of miRNA-125a. The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 µg/cm(2)/hr. Materials and Methods The enzymatic evaluation and antigenicity was finally studied. Image analysis software was used to determine the expressions of CD11a, CD11b, and CD11c integrins quantitatively. Conclusion: Materials and Methods: Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, … All 5 groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 50; 100; and 200 mg/KgBW. 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. In the previous year, we received 613 manuscripts for publication. As mitochondrial oxidative stress is probably entailed in ATP production, a candidate modifier factor for the long QT syndrome (LQTS) could be mitochondrial DNA (mtDNA). There was a significant association between sensitivity to mite and polymorphism of C allele of T1 SNP (P=0.02). 2- Control (C) group, administrated with distilled water via gavage. The seroprevalence of anti-H. pylori IgG was 74.2% and their rates increased with age. In mild hypothermia group, numbers of Fas-positive and MMP-3 positive cells were significantly less than those of normothermia group (P<0.05). Serum levels of leptin and soluble leptin receptor (sOB-R) were measured by ELISA method. Serum nitric oxide (NO) was assayed by colorimetric. Real-time PCR and western boltting were employed to examine the expression of cAMP responding-element binding protein (CREB). PC-12 cells were cultured under anoxic condition for induction of hypoxia injury and/or treatment with Quer, transfection with pre-miR-122, anti-miR-122 or their negative controls. ResultsIbuprofen particles obtained in the presence of surfactants consisted of numerous plate- shaped crystals which had agglomerated together as near spherical shape. Diabetes plays an important role in the induction of the liver injury. Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. This study demonstrates the beneficial effects of Zataria multiflora extract on insulin resistance in rats fed with a high-fructose diet through at least three mechanisms including direct insulin like effect, increasing in adiponectin and of PPARγ protein expression. Objective(s) Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, … In the current study formulations were characterized by loading efficiency, yield, particle size, zeta potential, X-ray diffraction (XRD) and differential scanning calorimetry (DSC).ResultsIn microparticles, the best drug to polymer ratio was 0.8:1 (F3). This work also throws some light on ionic channels present on these stem cells which are responsible for their neuron induction potential. They preferentially use these herbs and their products to treat multiple types of diseases due to their handiness and low cost (117). It has been notified that ion channels' activities in cardiomyocytes are sensitive to the ATP level. 11, Nov 2019 1227 An overview of the genus Cuscuta Noureen et al. Selection of the appropriate target site is essential in the success of an AO therapy. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Among carbapenem resistant isolates, 100% carried blaOXA-51-like, 82.47% carried blaOXA-23-like, 55.67% carried blaOXA-58-like, 22.68% carried blaOXA-40-like and 14.43% had blaOXA-143-like resistance genes. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. This study suggests that thiamine pyrophosphate may be useful in the prevention of I/R-related infertility in diabetics. Blood samples of these participants have been genotyped by PCR and the RFLP method. For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The genotype (QQ, QR, and RR) distributions were 25, 56, and 19 % in breast cancer cases and 54, 40, and 6% in controls, respectively. Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. Objective (s) Porin is a mitochondrial outer membrane channel, which usually functions as the pathway for the movement of various substances in and out of the mitochondria and is considered to be a component of the permeability transition (PT) pore complex that plays a role in the PT. Conclusion Results Iranian Journal of Basic Medical Sciences CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance Materials and Methods Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. 14 to 23; 2011 to 2020; Vol. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. Experimental rats were fed with high fructose diet for 6 weeks and then were treated with Z. multiflora extract or a pioglitazone solution for 2 weeks. Articles from Iranian Journal of Basic Medical Sciences are provided here courtesy of Mashhad University of Medical Sciences. Diabetes was induced by a single dose i.p. The increase in the protein expressions of CD11a, CD11b, and CD11c integrins may have an important role in the occurrence and development of myocardial hypertrophy. Quer could repress hypoxia-induced injury in PC-12 cells by activating AMPK and Wnt/β-catenin signaling pathways via down-regulation of miR-122. Results: The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. Objective(s)Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. Objective(s) Additionally, we found that miR-103 could directly target VEGF and thereby lead to the down-expression of VEGF. Also, miR-122 was down-regulated in Quer-treated cells. BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status. This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. Ropivacaine-treated rats exhibited significantly lower mean pulmonary artery pressure (mPAP), ratio of right ventricular weight to left ventricular plus septal weight (RV/(LV+S)) and wall thickness of pulmonary artery compared with those of control rats. Iranian Journal of Basic Medical Sciences Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain Gholam Ali Hamidi 1, Majid Jafari-Sabet 2, Alireza Abed 4, 5, Azam Mesdaghinia 1, 4, … Iranian Journal of Basic Medical Sciences In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme Azizeh Asadzadeh 1, Hajar Sirous 2, Morteza Pourfarzam 2, Parichehreh Yaghmaei 1, Afshin Fassihi 3* 1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran 167: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Considering the product's domestic demand and also low efficiency of production and pathogenicity of Streptococcus species, it is possible to produce it as recombinant product. Conclusion To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. The extract (25–250 mg/kg) administered 1 hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. Materials and Methods: D. aucheri has highly significant blood glucose lowering effect. miRNA-125a may regulate the apoptosis status of the NPCs by inhibiting the expression of its target gene BAK1, which provided a potential strategy for further development of IDD therapies. Considering the beneficial antidiabetic potential of A. marmelos, this study was conducted to evaluate the effect of chronic oral administration of A. marmelos as cognitive enhancer, on learning and spatial memory in diabetic rats using Morris water maze test.

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